Antibiotic and NSAID

Lung Protection Therapy – LPT

Lung Protection Therapy (LPT) is a simple respiratory disease treatment strategy to protect bovine lungs. It involves two therapies: (1) an antibiotic to kill or inhibit the disease-causing bacteria and (2) a non-steroidal anti-inflammatory drug (NSAID) to reduce the inflammation that leads to lung damage.

A Two-Pronged Strategy

Lung Protection Therapy (LPT) is a simple respiratory disease treatment strategy to protect bovine lungs. It works by combining the positive therapeutic benefits of an antibiotic to treat the bacterial infection and a non-steroidal anti-inflammatory drug (NSAID) to treat the inflammation associated with bovine respiratory disease.

An antibiotic alone is not enough to promote healthy lungs. While an antibiotic can control the bacteria that cause the disease, it has no effect on the inflammation that results from the disease. And it is the inflammation that causes lung damage and lung lesions. Once inflammation begins it creates a vicious cycle of more and more inflammation, more and more lung damage. That’s why an antibiotic alone is not enough – it takes the simultaneous control of inflammation via a non-steroidal anti-inflammatory drug (NSAID).

Cattle Lungs are Prone to Infection

Bovine lungs have 30% the capacity of equine lungs, yet cattle have 250% the oxygen requirement of horses. This capacity/oxygen requirement ratio makes bovine lungs highly susceptible to bacterial infection and lung damage. Every gram of lung tissue is valuable in fighting BRD infection and inflammation. The animals cannot afford to sacrifice even a small portion of lung to lesions. Lung Protection Therapy (LPT) can help. It combines the positive therapeutic benefits of an antibiotic to treat the bacterial infection and a non-steroidal anti-inflammatory drug (NSAID) to treat the inflammation associated with bovine respiratory disease.

Dr. Roder Discusses BRD & LPT

Dr. Joe Roder, Manager, Ruminant Technical Services at Merck Animal Health, discusses lung protection therapy in relation to bovine respiratory disease and how the dual treatment therapies – an antibiotic and non-steroidal anti-inflammatory drug – can prevent long term damage to the animal and its productivity potential.

Live interview from AABP 2009

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